Spondylosis is a type of arthritis where it affects spines. Wear and tear of spines which include spine discs and joints deteriorate.

Spondylosis could progress in a different part of the spine including (i) Middle of the spine (Thoracic), (ii) lower back (Lumbar), (iii) more than one part of the spine.

Spondylosis disease related to barre-lieou syndrome and degenerative disc disease. (Ref: MalaCards).

Gene related to Spondolysis is HTRA1 (HtrA Serine Peptidase 1). Located at chromosome 10( 10q26.13 ).

Chromosome 10. Location 10q26.13.

Human Phenotype Ontology:

HTRA1 is found in Dementia.
HTRA1 is found in Urinary incontinence.
HTRA1 is found in Autosomal recessive inheritance.
HTRA1 is found in CNS demyelination.
HTRA1 is found in Back pain.
HTRA1 is found in Pseudobulbar signs.
HTRA1 is found in Dysarthria.


Histone modification.

Summary of the Research Articles are as follows:

The prevalence and associated factors of symptomatic cervical Spondylosis in Chinese adults: a community-based cross-sectional study.

Prevalence of cervical spondylosis was high in Chinese population. People younger than 60 years were the focus of prevention for cervical spondylosis.

The symptoms and signs of cervical spondylosis:

The pain is increased by the movement.

Referred pain (occiput, between the shoulder blades, upper limbs).

Vague numbness, tingling, or weakness in upper limbs.

Dizziness or vertigo.

Poor balance.

Prevalence of lumbar spondylosis and its association with low back pain among community-dwelling Japanese women.

The research concluded that Lumbar spondylosis at L3/4, L4/5 or L5/S1 was associated with low back pain among community-dwelling Japanese women.